Tendon Stem Cell: A Possible Solution for Tendon Injury Repair and Aging
نویسندگان
چکیده
Tendon injuries due to misuse or overuse as well as agerelated degeneration are common clinical problems facing orthopedic surgeons and sports medicine clinicians. Following injury, tendons exhibit an ineffective repair response that is often characterized by scar formation. Severe tendon injuries often require surgical intervention, but the structure and function of repaired tendons remain inferior when compared to non-injured tendons [1]. The repair of injured tendons remains a great challenge, and becomes even more challenging in older patients. Currently, there are no therapies to restore the normal function and structure of injured tendons.
منابع مشابه
Use of Undifferentiated Cultured Bone Marrow-Derived Mesenchymal Stem Cells for DDF Tendon Injuries Repair in Rabbits: A Quantitative and Qualitative Histopathological Study
Objective- To investigate the effect of intratendinous injection of bMSCs on the rate and extent of tendon healing after primary repair in a rabbit model. Design- Experimental study. Animals- Twenty seven skeletally mature New Zealand white rabbits weighing 1.8- 2.5 kg were used. Twenty rabbits were used as the experimental animals, and seven others were used as a source of bone marrow-derived ...
متن کاملEffects of rabbit pinna-derived blastema cells on tendon healing
Objective(s): Tendon healing is substantially slow and often associated with suboptimal repair. Cell therapy is one of the promising methods to improve tendon repair. Blastema, a population of undifferentiated cells, represents characteristics of pluripotent mesenchymal stem cells and has the potentials to be used in regenerative medicine. The aim of this study was to ...
متن کاملبررسی تاثیر حرکت زودرس برعملکرد ترمیم تاندونهای فلکسور انگشتان دست
Abstract: Background: Immobilization and splinting after tendon repair, have traditionally been used as part of the treatment protocol for tendon injuries in fingers. There has always been a debate about the duration of immobilization among surgeons, because some complications after tendon repair are attributed to prolonged immobilization. In this study, the results of early mobilization follo...
متن کاملEffects of Non-Steroidal Anti-Inflammatory Drugs onFlexor Tendon Rehabilitation after Repair
Background: Peritendinous adhesions after repairing an injury to the digital flexor tendons are a major problem in hand surgery. Non-steroidal anti-inflammatory drug therapy may affect tendon healing and the development of peritendinous adhesions. The aim of this study was to evaluate ibuprofen effect in patients function after flexor tendon surgical repair. Method: Thirty-five patients, wh...
متن کاملAntioxidant Properties of Pistacia khinjuk Accelerate Healing of the Experimental Achilles Tendon Injury in Rabbits
Background: Delayed tendon healing and tendon adhesions are still found to be among the complications that occur most often after tendon repair. Pistacia khinjuk is one of the three species of Pistacia growing in Iran. Objective: In this study, the role of local injection of ethanolic extract of P. khinjuk was evaluated in healing of the experimental Achilles tendon injury in rabbits. Metho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014